NAD Supplements – How They Work

If you have ever sat back and watched school-age children run around the yard simply to burn off their excessive energy levels, you might have thought “Ah, those young mitochondria!”

If you didn’t think of that sentence exactly, it’s probably because you aren’t well-schooled on mitochondria and how important NAD supplements are in the anti-aging game.

Never heard of NAD or NAD supplements? That’s also not surprising since the research on this amazing substance is fairly new.

What is a NAD supplements, NAD+ supplements and what can they do for you? Let’s look at the science behind this product.

NAD supplements mitochondria

What are Mitochondria?

Think of mitochondria as the gas that runs the motor of our cells. Unfortunately, just like gasoline, mitochondria become unstable as we age.

Why this happens isn’t clear, but weak mitochondria has been linked to a great many age-related health problems, including neurodegeneration, heart failure, and, apparently, running around the yard for the heck of it.

What is NAD?

NAD is short for nicotinamide adenine dinucleotide. Think of NAD as the backbone of energy metabolism. Without NAD, life would not exist because there would be no energy to drive it. NAD levels also decrease as we age. Lower NAD levels are believed to impair the function of our mitochondria. Since NAD declines as we age, our mitochondrial function also declines. By keeping NAD levels steady, the aging process, and the health problems that go along with it, might also be delayed.

What is NAD+?

Without getting into a full chemistry class explanation, NAD is involved in what is called oxidation-reduction reactions. This means that NAD will have an oxidized form and a reduced form. An oxidized form of NAD is written as NAD+. The reduced form of NAD is written as NADH, often simply called NAD.

What Are SIRT1 and SIRT3?

One last science lesson, we promise. There are millions of enzymes in the body, but for this discussion, we want to focus on two, SIRT1 and SIRT2.

These two enzymes belong to a special group of enzymes called sirtuins. NAD+ activates these enzymes, which lead to healthier mitochondria, which boils down to a much slower aging process.  

What Does This Mean for Me?

As we age, our NAD+ levels begin to fall off. This leads to less activation of sirtuins, which then causes your mitochondria to deteriorate. This is the normal aging process that causes heart problems, achy joints, less active brains, and falling energy levels.

Now imagine what would happen if we could control the levels of NAD in the body. We would be able to stimulate our sirtuins, slow down the deterioration of our mitochondria, which means slowing down the aging process in general. Slower aging = a longer lifespan.

NAD supplements scientists

What Does Science Say about This?

Science has a lot to say about this and so far, it’s all been amazing.

While NAD+ has been known to scientists since 1906, the important role it plays in the anti-aging process and longevity has only been discovered in the early 2000’s.  

In 2006, Harvard released a study involving mice that were bred to have defective SIRT1. The mice aged quickly because of this and had serious problems with the breakdown of their mitochondria.

When these test subjects were 22 months old, they were given NAD+ injections for one week. The results were that these mice had significant improvements in their health including:

  • Lower levels of inflammation
  • Improved muscle growth
  • Less resistance to insulin.

In this study, the mice began to make new tissue that resembled the tissue of a mouse that was only 6 months old. This would be like a 60-year-old human making new tissue that would be more like a 20-year-old. Researchers found that the mice acted younger, looked younger (in terms of muscle and physical abilities) and lived longer than the typical indoor mouse, which is usually 24-36 months. In fact, within 1 week of being given NAD+, researchers stated that they could no longer tell the difference between the nearly 2 year old mice and a 6 month old mouse.

Of course, this isn’t to suggest that NAD+ supplements can make humans immortal or even keep us looking like we are 25, but imagine looking and feeling younger, with all that energy that makes you want to play tag before dinner, right up through our “golden years”?

Also, while there have been multiple studies in laboratories and involving mice, tests on humans are still being conducted, but the results from completed tests have been nothing short of astounding.

NAD supplements extreme excercise

Are There Other Ways to Increase NAD+?

Yes. A very restricted calorie diet has been shown to increase NAD+ in the body, as well as vigorous exercise, but you can’t get the same levels of NAD+ that a supplement will provide. Not only that, but let’s be honest; how many people are willing to stick to a very low-calorie diet and strenuous physical exercise for very long?

In a Nutshell

NAD+ is a coenzyme that is necessary for life itself. It plays many important roles in our health including stimulating the activity of sirtuins, DNA damage repair, and keeping our mitochondria healthy. Low NAD+ levels are associated with low energy, age-related diseases, a slower metabolism, and lower cognitive function.

NAD+ levels decline as we age. By keeping NAD+ at steady levels equal to our younger days, the aging process can be slowed, while keeping the body in a younger, healthier state.

Since NAD+ is a natural coenzyme in the body, you don’t have to worry about side effects, allergies, or other reactions to this compound.

What If?

What if you could get everything you needed in easy to take NAD supplements? Wouldn’t that be a terrific one-stop-keeps-you-younger supplement?

Anti-aging, improved health, lower risk of heart disease, and improved brain function all in one?

Think of the possibilities! An almost futuristic version of the proverbial “fountain of youth” in a bottle!

Further research and testing involving humans is currently ongoing.

Watch this space for more details. Coming soon.


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